| | |  | | | | Record from Web of Science® | | | | | | |
| Computational comparison of two draft sequences of the human genome |
|
|
| Author(s): Aach J, Bulyk ML, Church GM, Comander J, Derti A, Shendure J |
| Source: NATURE Volume: 409 Issue: 6822 Pages: 856-859 Published: FEB 15 2001 |
| Times Cited: 31 References: 20 |
| Abstract: We are in the enviable position of having two distinct drafts of the human genome sequence. Although gaps, errors, redundancy and incomplete annotation mean that individually each falls short of the ideal, many of these problems can be assessed by comparison. Here we present some comparative analyses of these drafts. We look at a number of features of the sequences, including sequence gaps, continuity, consistency between the two sequences and patterns of DNA-binding protein motifs. |
| Document Type: Article |
| Language: English |
| Reprint Address: Church, GM (reprint author), Harvard Univ, Sch Med, Lipper Ctr Computat Genet, Boston, MA 02115 USA |
Addresses:
1. Harvard Univ, Sch Med, Lipper Ctr Computat Genet, Boston, MA 02115 USA
2. Harvard Univ, Sch Med, Program Biophys, Boston, MA 02115 USA
3. Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA
4. Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
5. Boston Univ, Program Bioinformat, Boston, MA 02215 USA |
| Publisher: MACMILLAN PUBLISHERS LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 401QC |
| ISSN: 0028-0836 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |