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| Presynaptic calcium stores underlie large-amplitude miniature IPSCs and spontaneous calcium transients |
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| Author(s): Llano I, Gonzalez J, Caputo C, Lai FA, Blayney LM, Tan YP, Marty A |
| Source: NATURE NEUROSCIENCE Volume: 3 Issue: 12 Pages: 1256-1265 Published: DEC 2000 |
| Times Cited: 184 References: 49 |
| Abstract: The cellular mechanisms responsible for large miniature currents in some brain synapses remain undefined. In Purkinje cells, we found that large-amplitude miniature inhibitory postsynaptic currents (mIPSCs) were inhibited by ryanodine or by long-term removal of extracellular Ca2+. Two-photon Ca2+ imaging revealed random, ryanodine-sensitive intracellular Ca2+ transients, spatially constrained at putative presynaptic terminals. At high concentration, ryanodine decreased action-potential-evoked rises in intracellular Ca2+. Immuno-localization showed ryanodine receptors in these terminals. Our data suggest that large mIPSCs are multivesicular events regulated by Ca2+ release from ryanodine-sensitive presynaptic Ca2+ stores. |
| Document Type: Article |
| Language: English |
| Reprint Address: Llano, I (reprint author), Max Planck Inst Biophys Chem, Arbeitsgrp Zellulare Neurobiol, D-37077 Gottingen, Germany |
Addresses:
1. Max Planck Inst Biophys Chem, Arbeitsgrp Zellulare Neurobiol, D-37077 Gottingen, Germany
2. Inst Venezolano Invest Cient, Ctr Biofis, Caracas 1020A, Venezuela
3. Univ Wales, Div Med Cardiol, Cardiff CF4 4XN, S Glam Wales
4. Bogazici Univ, Istanbul, Turkey |
| Publisher: NATURE AMERICA INC, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 USA |
| Subject Category: Neurosciences |
| IDS Number: 405UA |
| ISSN: 1097-6256 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |