| | |  | | | | Record from Web of Science® | | | | | | |
| Chronic systemic pesticide exposure reproduces features of Parkinson's disease |
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| Author(s): Betarbet R, Sherer TB, MacKenzie G, Garcia-Osuna M, Panov AV, Greenamyre JT |
| Source: NATURE NEUROSCIENCE Volume: 3 Issue: 12 Pages: 1301-1306 Published: DEC 2000 |
| Times Cited: 1,092 References: 41 |
| Abstract: The cause of Parkinson's disease (PD) is unknown, but epidemiological studies suggest an association with pesticides and other environmental toxins, and biochemical studies implicate a systemic defect in mitochondrial complex I. We report that chronic, systemic inhibition of complex I by the lipophilic pesticide, rotenone, causes highly selective nigrostriatal dopaminergic degeneration that is associated behaviorally with hypokinesia and rigidity. Nigral neurons in rotenone-treated rats accumulate fibrillar cytoplasmic inclusions that contain ubiquitin and alpha -synuclein. These results indicate that chronic exposure to a common pesticide can reproduce the anatomical, neurochemical, behavioral and neuropathological features of PD. |
| Document Type: Article |
| Language: English |
| Reprint Address: Greenamyre, JT (reprint author), Emory Univ, Dept Neurol, 1639 Pierce Dr,WMB 6000, Atlanta, GA 30322 USA |
Addresses:
1. Emory Univ, Dept Neurol, Atlanta, GA 30322 USA |
| Publisher: NATURE AMERICA INC, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 USA |
| Subject Category: Neurosciences |
| IDS Number: 405UA |
| ISSN: 1097-6256 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |