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| Molecular interaction maps as information organizers and simulation guides |
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| Author(s): Kohn KW |
| Source: CHAOS Volume: 11 Issue: 1 Pages: 84-97 Published: MAR 2001 |
| Times Cited: 34 References: 46 |
| Abstract: A graphical method for mapping bioregulatory networks is presented that is suited for the representation of multimolecular complexes, protein modifications, as well as actions at cell membranes and between protein domains. The symbol conventions defined for these molecular interaction maps are designed to accommodate multiprotein assemblies and protein modifications that can generate combinatorially large numbers of molecular species. Diagrams can either be "heuristic," meaning that detailed knowledge of all possible reaction paths is not required, or "explicit," meaning that the diagrams are totally unambiguous and suitable for simulation. Interaction maps are linked to annotation lists and indexes that provide ready access to pertinent data and references, and that allow any molecular species to be easily located. Illustrative interaction maps are included on the domain interactions of Src, transcription control of E2F-regulated genes, and signaling from receptor tyrosine kinase through phosphoinositides to Akt/PKB. A simple method of going from an explicit interaction diagram to an input file for a simulation program is outlined, in which the differential equations need not be written out. The role of interaction maps in selecting and defining systems for modeling is discussed. (C) 2001 American Institute of Physics. |
| Document Type: Article |
| Language: English |
| Reprint Address: Kohn, KW (reprint author), NCI, Mol Pharmacol Lab, Div Basic Sci, Bethesda, MD 20892 USA |
Addresses:
1. NCI, Mol Pharmacol Lab, Div Basic Sci, Bethesda, MD 20892 USA |
| Publisher: AMER INST PHYSICS, 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA |
| Subject Category: Mathematics, Applied; Physics, Mathematical |
| IDS Number: 407ZJ |
| ISSN: 1054-1500 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |