| | |  | | | | Record from Web of Science® | | | | | | |
| Cell fate decision: T-helper 1 and 2 subsets in immune responses |
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| Author(s): Dong C, Flavell RA |
| Source: ARTHRITIS RESEARCH Volume: 2 Issue: 3 Pages: 179-188 Published: 2000 |
| Times Cited: 49 References: 108 |
| Abstract: After activation CD4(+) helper T cells differentiate into T-helper (Th)1 or Th2 effector cells. These two subsets are characterized by their distinct cytokine expression pattern and the immune function they mediate. Over the past years, a number of factors have been identified to affect helper T cell lineage determination, including antigen receptor, coreceptors and, most importantly, cytokine environment. In this review, we also summarize recent advancement in understanding of transcriptional and signaling regulation of the differentiation process. This knowledge will become important in the future to develop means in treating immune disorders. |
| Document Type: Review |
| Language: English |
| Reprint Address: Flavell, RA (reprint author), Yale Univ, Sch Med, Howard Hughes Med Inst, Immunobiol Sect, FMB 412,310 Cedar St, New Haven, CT 06520 USA |
Addresses:
1. Yale Univ, Sch Med, Howard Hughes Med Inst, Immunobiol Sect, New Haven, CT 06520 USA |
| Publisher: BIOMED CENTRAL LTD, MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1P 6LB, ENGLAND |
| Subject Category: Rheumatology |
| IDS Number: 408ZU |
| ISSN: 1465-9913 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |