| | |  | | | | Record from Web of Science® | | | | | | |
| In vitro and in vivo estrogenicity of UV screens |
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| Author(s): Schlumpf M, Cotton B, Conscience M, Haller V, Steinmann B, Lichtensteiger W |
| Source: ENVIRONMENTAL HEALTH PERSPECTIVES Volume: 109 Issue: 3 Pages: 239-244 Published: MAR 2001 |
| Times Cited: 161 References: 37 |
| Abstract: Ultraviolet (UV) screens are increasingly used as a result of growing concern about UV radiation and skin cancer; they are also added to cosmetics and other products for light stability. Recent data on bioaccumulation in wildlife and humans point to a need for in-depth analyses of systemic toxicology, in particular with respect to reproduction and ontogeny. We examined six frequently used UVA and UVB screens for estrogenicity in vitro and in vivo. In MCF-7 breast cancer cells, five out of six chemicals, that is, benzophenone-3 (Bp-3), homosalate (HMS), 4-methyl-benzylidene camphor (4-MBC), octyl-methoxycinnamate (OMC), and octyl-dimethyl-PABA (OD-PABA), increased cell proliferation with median effective concentrations (EC50) values between 1.56 and 3.73 muM, whereas butyl-methoxydibenzoylmethane (B-MDM) was inactive. Further evidence for estrogenic activity was the induction of pS2 protein in MCF-7 cells and the blockade of the proliferative effect of 4-MBC by the estrogen antagonist ICI 182,780. In the uterotrophic assay using immature Long-Evans rate that received the chemicals for 4 days in powdered feed, uterine weight was dose-dependently increased by 4-MBC (ED50 309mg/kg/day), OMC (ED50 935 mg/kg/day), and weakly by Bp-3 (active at 1,525 mg/kg/day). Three compounds were inactive by the oral route in the doses tested. Dermal application of 4-MBC to immature hairless (hr/hr) rats also increased uterine weight at concentrations of 5 and 7.5% in olive oil. Our findings indicate that UV screens should be tested for endocrine activity, in view of possible long-term effects in humans and wildlife. |
| Document Type: Proceedings Paper |
| Language: English |
| Reprint Address: Schlumpf, M (reprint author), Univ Zurich, Inst Pharmacol & Toxicol, Winterthurerstr 190, CH-8057 Zurich, Switzerland |
Addresses:
1. Univ Zurich, Inst Pharmacol & Toxicol, CH-8057 Zurich, Switzerland |
| Publisher: US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE, NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA |
| Subject Category: Environmental Sciences; Public, Environmental & Occupational Health |
| IDS Number: 416HQ |
| ISSN: 0091-6765 |
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