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| An abundance of X-linked genes expressed in spermatogonia |
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| Author(s): Wang PJ, McCarrey JR, Yang F, Page DC |
| Source: NATURE GENETICS Volume: 27 Issue: 4 Pages: 422-426 Published: APR 2001 |
| Times Cited: 292 References: 30 |
| Abstract: Spermatogonia are the self-renewing, mitotic germ cells of the testis from which sperm arise by means of the differentiation pathway known as spermatogenesis'. By contrast with hematopoietic and other mammalian stem-cell populations. which have been subjects of intense molecular genetic investigation, spermatogonia have remained largely unexplored at the molecular level. Here we describe a systematic search for genes expressed in mouse spermatogonia, but not in somatic tissues. We identified 25 genes (19 of which are novel) that are expressed in only mate germ cells. Of the 25 genes, 3 are Y-linked and 10 are X-linked. If these genes had been distributed randomly in the genome, one would have expected zero to two of the genes to be X-linked. Our findings indicate that the X chromosome has a predominant role in pre-meiotic stages of mammalian spermatogenesis. We hypothesize that the X chromosome acquired this prominent role in male germ-cell development as it evolved from an ordinary, unspecialized autosome. |
| Document Type: Article |
| Language: English |
| Reprint Address: Page, DC (reprint author), MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA |
Addresses:
1. MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
2. MIT, Whitehead Inst, Cambridge, MA USA
3. MIT, Dept Biol, Cambridge, MA USA
4. SW Fdn Biomed Res, Dept Genet, San Antonio, TX USA |
| Publisher: NATURE AMERICA INC, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 USA |
| Subject Category: Genetics & Heredity |
| IDS Number: 416ZU |
| ISSN: 1061-4036 |
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