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| A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function |
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| Author(s): Tatar M, Kopelman A, Epstein D, Tu MP, Yin CM, Garofalo RS |
| Source: SCIENCE Volume: 292 Issue: 5514 Pages: 107-110 Published: APR 6 2001 |
| Times Cited: 488 References: 29 |
| Abstract: The Drosophila melanogaster gene insulin-like receptor (InR) is homologous to mammalian insulin receptors as well as to Caenorhabditis elegans daf-2, a signal transducer regulating worm dauer formation and adult Longevity. We describe a heteroallelic, hypomorphic genotype of mutant InR, which yields dwarf females with up to an 85% extension of adult longevity and dwarf males with reduced Late age-specific mortality. Treatment of the Long-lived InR dwarfs with a juvenile hormone analog restores Life expectancy toward that of wild-type controls. We conclude that juvenile hormone deficiency, which results from InR signal pathway mutation, is sufficient to extend life-span, and that in flies, insulin-like Ligands nonautonomously mediate aging through retardation of growth or activation of specific endocrine tissue. |
| Document Type: Article |
| Language: English |
| Reprint Address: Tatar, M (reprint author), Brown Univ, Providence, RI 02912 USA |
Addresses:
1. Brown Univ, Providence, RI 02912 USA
2. Univ Massachusetts, Amherst, MA 01003 USA
3. Pfizer Inc, Global Res & Dev, Groton, CT 06340 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 420FU |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |