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| Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation |
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| Author(s): Ebisawa T, Fukuchi M, Murakami G, Chiba T, Tanaka K, Imamura T, Miyazono K |
| Source: JOURNAL OF BIOLOGICAL CHEMISTRY Volume: 276 Issue: 16 Pages: 12477-12480 Published: APR 20 2001 |
| Times Cited: 289 References: 20 |
| Abstract: Smad7 is an inhibitory Smad that acts as a negative regulator of signaling by the transforming growth factor-beta (TGF-beta) superfamily proteins. Smad7 is induced by TGF-beta, stably interacts with activated TGF-beta type I receptor (T betaR-I), and interferes with the phosphorylation of receptor-regulated Smads. Here we show that Smurf1, an E3 ubiquitin ligase for bone morphogenetic protein-specific Smads, also interacts with Smad7 and induces Smad7 ubiquitination and translocation into the cytoplasm. In addition, Smurf1 associates with T betaR-I via Smad7, with subsequent enhancement of turnover of T betaR-I and Smad7. These results thus reveal a novel function of Smad7, i.e. induction of degradation of T betaR-I through recruitment of an E3 ligase to the receptor. |
| Document Type: Article |
| Language: English |
| Reprint Address: Miyazono, K (reprint author), Japanese Fdn Canc Res, Inst Canc, Dept Biochem, Toshima Ku, 1-37-1 Kami Ikebukuro, Tokyo 1708455, Japan |
Addresses:
1. Japanese Fdn Canc Res, Inst Canc, Dept Biochem, Toshima Ku, Tokyo 1708455, Japan
2. Japanese Fdn Canc Res, Res Future Program, Toshima Ku, Tokyo 1708455, Japan
3. Tokyo Metropolitan Inst Med Sci, Bunkyo Ku, Tokyo 1138613, Japan
4. Univ Tokyo, Dept Mol Pathol, Grad Sch Med, Bunkyo Ku, Tokyo 1130033, Japan |
| Publisher: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA |
| Subject Category: Biochemistry & Molecular Biology |
| IDS Number: 423VN |
| ISSN: 0021-9258 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |