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| IFN gamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity |
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| Author(s): Shankaran V, Ikeda H, Bruce AT, White JM, Swanson PE, Old LJ, Schreiber RD |
| Source: NATURE Volume: 410 Issue: 6832 Pages: 1107-1111 Published: APR 26 2001 |
| Times Cited: 548 References: 21 |
| Abstract: Lymphocytes were originally thought to form the basis of a 'cancer immunosurveillance' process that protects immunocompetent hosts against primary tumour development(1,2), but this idea was largely abandoned when no differences in primary tumour development were found between athymic nude mice and syngeneic wild-type mice(3-5). However, subsequent observations that nude mice do not completely lack functional T cells(6,7) and that two components of the immune system-IFN gamma (8,9) and perforin(10-12)-help to prevent tumour formation in mice have led to renewed interest in a tumour-suppressor role for the immune response. Here we show that lymphocytes and IFN gamma collaborate to protect against development of carcinogen-induced sarcomas and spontaneous epithelial carcinomas and also to select for tumour cells with reduced immunogenicity. The immune response thus functions as an effective extrinsic tumour-suppressor system. However, this process also leads to the immunoselection of tumour cells that are more capable of surviving in an immunocompetent host, which explains the apparent paradox of tumour formation in immunologically intact individuals. |
| Document Type: Article |
| Language: English |
| Reprint Address: Schreiber, RD (reprint author), Washington Univ, Sch Med, Ctr Immunol, Dept Pathol & Immunol, 660 S Euclid Ave, St Louis, MO 63110 USA |
Addresses:
1. Washington Univ, Sch Med, Ctr Immunol, Dept Pathol & Immunol, St Louis, MO 63110 USA
2. Mem Sloan Kettering Canc Ctr, New York Branch, Ludwig Inst Canc Res, New York, NY 10021 USA |
| Publisher: MACMILLAN PUBLISHERS LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 425HQ |
| ISSN: 0028-0836 |
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