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| Diagnosis of cardiac sarcoidosis and evaluation of the effects of steroid therapy by gadolinium-DTPA-enhanced magnetic resonance imaging |
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| Author(s): Shimada T, Shimada K, Sakane T, Ochiai K, Tsukihashi H, Fukui M, Inoue S, Katoh H, Murakami Y, Ishibashi Y, Maruyama R |
| Source: AMERICAN JOURNAL OF MEDICINE Volume: 110 Issue: 7 Pages: 520-527 Published: MAY 2001 |
| Times Cited: 76 References: 35 |
| Abstract: BACKGROUND: Cardiac involvement is an important prognostic factor in patients with sarcoidosis. In this study, we evaluated the usefulness of gadolinium-DTPA (diethylene triamine pentaacetic acid)-enhanced magnetic resonance imaging (Gd-MRI) for diagnosing cardiac sarcoidosis and evaluating the effects of steroid therapy. METHODS: Sixteen patients with sarcoidosis diagnosed by histology or by Japanese Ministry of Health and Welfare criteria for cardiac sarcoidosis underwent Gd-MRI with a 1.5-Tesla superconducting magnet system using a TI-weighted spin-echo sequence.
RESULTS: Gd-MRI showed localized enhancement of signal intensity, indicating interstitial edema, in the left ventricle in 8 of the 16 patients. Two patients with enhance inc nt also had thinning of the left ventricular septal wall. After 1 month of prednisolene therapy (60 mg every other day or 30 to 40 mg every day), the localized high-intensity signals were markedly diminished in all 8 patients,
CONCLUSIONS: Images of the heart obtained by Sd-MRI may reflect active inflammation with interstitial edema in patients with sarcoidosis. Gd-MRI may be a useful noninvasive method for early detection of cardiac sarcoidosis and for evaluating the effects of steroid therapy. (C) 2001 by Excerpta Medica, Inc.
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| Document Type: Article |
| Language: English |
| Reprint Address: Shimada, T (reprint author), Shimane Med Univ, Dept Internal Med, Div Cardiovasc, 89-1 Enya Cho, Izumo, Shimane 6938501 Japan |
Addresses:
1. Shimane Med Univ, Dept Internal Med, Div Cardiovasc, Izumo, Shimane 6938501 Japan
2. Shimane Univ, Div Pathol Lab, Izumo, Shimane 6938501 Japan
3. Shiga Med Ctr Adults, Div Resp, Shiga, Japan |
| Publisher: EXCERPTA MEDICA INC, 650 AVENUE OF THE AMERICAS, NEW YORK, NY 10011 USA |
| Subject Category: Medicine, General & Internal |
| IDS Number: 430CM |
| ISSN: 0002-9343 |
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