| | |  | | | | Record from Web of Science® | | | | | | |
| Bacterial fatty-acid biosynthesis: a genomics-driven target for antibacterial drug discovery |
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| Author(s): Payne DJ, Warren PV, Holmes DJ, Ji YD, Lonsdale JT |
| Source: DRUG DISCOVERY TODAY Volume: 6 Issue: 10 Pages: 537-544 Published: MAY 15 2001 |
| Times Cited: 56 References: 46 |
| Abstract: In this review we demonstrate how the interplay of genomics, bioinformatics and genomic technologies has enabled an in-depth analysis of the component enzymes of the bacterial fatty-acid biosynthesis pathway as a source of novel antibacterial targets. This evaluation has revealed that many of the enzymes are potentially selective, broad-spectrum antibacterial targets. We also illustrate the suitability of some of these targets for HTS. Furthermore, we discuss how the availability of a robust selectivity assay, mode-of-action assays and numerous crystal structures provide an excellent set of tools with which to initiate integrated programs of research to identify novel antibiotics targeted at these enzymes. |
| Document Type: Review |
| Language: English |
| Reprint Address: Payne, DJ (reprint author), GlaxoSmithKline, Bioinformat, 1250 S Collegeville Rd, Collegeville, PA 19426 USA |
Addresses:
1. GlaxoSmithKline, Bioinformat, Collegeville, PA 19426 USA |
| Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND |
| Subject Category: Pharmacology & Pharmacy |
| IDS Number: 432VT |
| ISSN: 1359-6446 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |