| | |  | | | | Record from Web of Science® | | | | | | |
| Resting and activated endothelial cells are increased in the peripheral blood of cancer patients |
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| Author(s): Mancuso P, Burlini A, Pruneri G, Goldhirsch A, Martinelli G, Bertolini F |
| Source: BLOOD Volume: 97 Issue: 11 Pages: 3658-3661 Published: JUN 1 2001 |
| Times Cited: 173 References: 20 |
| Abstract: Circulating endothelial cells (CECs) were enumerated in 20 healthy controls and 76 newly diagnosed cancer patients by means of a-color flow cytometry. In breast cancer (n = 46) and lymphoma (n = 30) patients, both resting and activated CECs were increased by 5-fold (P < .0008 vs control). CECs significantly correlated with plasma levels of vascular cell adhesion molecule-1 and vascular endothelial growth factor. Resting and activated CECs were similar to healthy controls in 7 lymphoma patients achieving complete remission after chemotherapy, and activated CECs were found to decrease in 13 breast cancer patients evaluated before and 24 hours after quadrantectomy. |
| Document Type: Article |
| Language: English |
| Reprint Address: Bertolini, F (reprint author), European Inst Oncol, Div Hematol Oncol, Via Ripamonti 435, I-20141 Milan, Italy |
Addresses:
1. European Inst Oncol, Div Hematol Oncol, I-20141 Milan, Italy
2. European Inst Oncol, Div Pathol Lab Med, I-20141 Milan, Italy
3. European Inst Oncol, Div Med Oncol, I-20141 Milan, Italy |
| Publisher: AMER SOC HEMATOLOGY, 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA |
| Subject Category: Hematology |
| IDS Number: 436GJ |
| ISSN: 0006-4971 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |