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| Primary immunodeficiency diseases: an experimental model for molecular medicine |
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| Author(s): Fischer A |
| Source: LANCET Volume: 357 Issue: 9271 Pages: 1863-1869 Published: JUN 9 2001 |
| Times Cited: 56 References: 61 |
| Abstract: Primary immunodeficiency diseases represent a vast array of inherited disorders of the immune system. Major advances in the understanding of genetic basis and molecular mechanisms have occurred within the past 10 years, as a result of the tools of modern genetics. About three quarters of 100 primary immunodeficiency diseases can now be reliably diagnosed with molecular probes. In many cases, gene identification has enabled significant insight into the physiopathology of the related conditions. Therapeutic progress based on protein engineering and possibly gene therapy will also ensue. |
| Document Type: Article |
| Language: English |
| Reprint Address: Fischer, A (reprint author), Hop Necker Enfants Malad, INSERM, U429, 149 Rue Sevres, F-75015 Paris, France |
Addresses:
1. Hop Necker Enfants Malad, INSERM, U429, F-75015 Paris, France |
| Publisher: LANCET LTD, 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND |
| Subject Category: Medicine, General & Internal |
| IDS Number: 440DN |
| ISSN: 0140-6736 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |