| | |  | | | | Record from Web of Science® | | | | | | |
| The epidemic behavior of the hepatitis C virus |
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| Author(s): Pybus OG, Charleston MA, Gupta S, Rambaut A, Holmes EC, Harvey PH |
| Source: SCIENCE Volume: 292 Issue: 5525 Pages: 2323-2325 Published: JUN 22 2001 |
| Times Cited: 126 References: 36 |
| Abstract: Hepatitis C virus (HCV) is a leading worldwide cause of liver disease. Here, we use a new model of HCV spread to investigate the epidemic behavior of the virus and to estimate its basic reproductive number from gene sequence data. We find significant differences in epidemic behavior among HCV subtypes and suggest that these differences are largely the result of subtype-specific transmission patterns. Our model builds a bridge between the disciplines of population genetics and mathematical epidemiology by using pathogen gene sequences to infer the population dynamic history of an infectious disease. |
| Document Type: Article |
| Language: English |
| Reprint Address: Pybus, OG (reprint author), Univ Oxford, Dept Zool, S Parks Rd, Oxford OX1 3PS, England |
Addresses:
1. Univ Oxford, Dept Zool, Oxford OX1 3PS, England |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 445KD |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |