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Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
Author(s): McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, McFarland HF, Paty DW, Polman CH, Reingold SC, Sandberg-Wollheim M, Sibley W, Thompson AJ, van den Noort S, Weinshenker BY, Wolinsky JS
Source: ANNALS OF NEUROLOGY    Volume: 50    Issue: 1    Pages: 121-127    Published: JUL 2001  
Times Cited: 1,933     References: 23     
Abstract: The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with clinical and other paraclinical diagnostic methods. The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including "monosymptomatic" disease suggestive of MS, disease with a typical relapsing-remitting course, and disease with insidious progression, without clear attacks and remissions. Previously used terms such as "clinically definite" and "probable MS" are no longer recommended. The outcome of a diagnostic evaluation is either MS, "possible MS" (for those at risk for MS, but for whom diagnostic evaluation is equivocal), or "not MS."
Document Type: Article
Language: English
Reprint Address: McDonald, WI (reprint author), Royal Coll Physicians, 11 St Andrews Pl, London NW1 4LE, England
Addresses:
1. Royal Coll Physicians, London NW1 4LE, England
2. Univ Cambridge, Cambridge, England
3. CHU Rennes, Rennes, France
4. Univ Calif San Francisco, San Francisco, CA 94143 USA
5. Karl Franzens Univ Graz, Graz, Austria
6. Mt Sinai Sch Med, New York, NY USA
7. Natl Inst Neurol Disorders & Stroke, Bethesda, MD USA
8. Univ British Columbia, Vancouver, BC V5Z 1M9 Canada
9. Free Univ Amsterdam, NL-1081 HV Amsterdam, Netherlands
10. Natl Multiple Sclerosis Soc, New York, NY USA
11. Univ Lund Hosp, S-22185 Lund, Sweden
12. UCL, Inst Neurol, London, England
13. Univ Arizona, Hlth Sci Ctr, Tucson, AZ USA
14. Neurol Inst, London, England
15. Univ Calif Irvine, Irvine, CA USA
16. Mayo Clin & Mayo Fdn, Rochester, MN 55905 USA
17. Univ Texas, Hlth Sci Ctr, Houston, TX USA
Publisher: WILEY-LISS, DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA
Subject Category: Clinical Neurology; Neurosciences
IDS Number: 447FR
ISSN: 0364-5134
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