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| Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia |
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| Author(s): Ma ZG, Morris SW, Valentine V, Li M, Herbrick JA, Cui XL, Bouman D, Li Y, Mehta PK, Nizetic D, Kaneko Y, Chan GCF, Chan LC, Squire J, Scherer SW, Hitzler JK |
| Source: NATURE GENETICS Volume: 28 Issue: 3 Pages: 220-221 Published: JUL 2001 |
| Times Cited: 89 References: 15 |
| Abstract: t(1;22) is the principal translocation of acute megakaryoblastic leukemias. Here we show this chromosomal rearrangement to result in the fusion of two novel genes. RNA-binding motif protein-15 (RBM15). an RNA recognition motif-encoding gene with homology to Drosophila spen. and Megakaryoblastic Leukemia-1 (MKL1), a gene encoding an SAP (SAF-A/B. Acinus and PIAS) DNA-binding domain. |
| Document Type: Article |
| Language: English |
| Reprint Address: Hitzler, JK (reprint author), Univ Toronto, Hosp Sick Children, Dept Paediat, Div Haematol Oncol, Toronto, ON M5G 1X8 Canada |
Addresses:
1. Univ Toronto, Hosp Sick Children, Dept Paediat, Div Haematol Oncol, Toronto, ON M5G 1X8 Canada
2. Univ Toronto, Hosp Sick Children, Dept Canc & Blood, Toronto, ON M5G 1X8 Canada
3. Univ Toronto, Hosp Sick Children, Dept Genet, Toronto, ON M5G 1X8 Canada
4. St Jude Childrens Res Hosp, Dept Pathol, Memphis, TN 38105 USA
5. St Jude Childrens Res Hosp, Dept Tumor Cell Biol, Memphis, TN 38105 USA
6. St Jude Childrens Res Hosp, Dept Hematol Oncol, Memphis, TN 38105 USA
7. St Jude Childrens Res Hosp, Hartwell Ctr Bioinformat & Biotechnol, Memphis, TN 38105 USA
8. Univ Tennessee, Coll Med, Dept Pediat, Memphis, TN 38163 USA
9. Univ London, Sch Pharm, Ctr Appl Mol Biol, London WC1N 1AX, England
10. Saitama Canc Ctr Hosp, Dept Canc Chemotherapy, Ina, Saitama 3630806 Japan
11. Univ Hong Kong, Queen Mary Hosp, Dept Paediat, Div Haematol, Hong Kong, Hong Kong Peoples R China
12. Univ Hong Kong, Queen Mary Hosp, Dept Pathol, Div Haematol, Hong Kong, Hong Kong Peoples R China
13. Univ Toronto, Dept Med Biophys, Toronto, ON M5S 1A8 Canada
14. Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5S 1A8 Canada
15. Univ Toronto, Dept Mol & Med Genet, Toronto, ON M5S 1A8 Canada |
| Publisher: NATURE AMERICA INC, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 USA |
| Subject Category: Genetics & Heredity |
| IDS Number: 448XZ |
| ISSN: 1061-4036 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |