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| Signals transduced by Ca2+/calcineurin and NFATc3/c4 pattern the developing vasculature |
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| Author(s): Graef IA, Chen F, Chen L, Kuo A, Crabtree GR |
| Source: CELL Volume: 105 Issue: 7 Pages: 863-875 Published: JUN 29 2001 |
| Times Cited: 180 References: 45 |
| Abstract: Vascular development requires an orderly exchange of signals between growing vessels and their supporting tissues, but little is known of the intracellular signaling pathways underlying this communication. We find that mice with disruptions of both NFATc4 and the related NFATc3 genes die around E11 with generalized defects in vessel assembly as well as excessive and disorganized growth of vessels into the neural tube and somites. Since calcineurin is thought to control nuclear localization of NFATc proteins, we introduced a mutation into the calcineurin a gene that prevents phosphatase activation by Ca2+ signals. These CnB mutant mice exhibit vascular developmental abnormalities similar to the NFATc3/c4 null mice. We show that calcineurin function is transiently required between E7.5 and E8.5. Hence, early calcineurin/NFAT signaling initiates the later cross-talk between vessels and surrounding tissues that pattern the vasculature. |
| Document Type: Article |
| Language: English |
| Reprint Address: Crabtree, GR (reprint author), Stanford Univ, Howard Hughes Med Inst, Dept Dev Biol, Stanford, CA 94305 USA |
Addresses:
1. Stanford Univ, Howard Hughes Med Inst, Dept Dev Biol, Stanford, CA 94305 USA
2. Stanford Univ, Howard Hughes Med Inst, Dept Pathol, Stanford, CA 94305 USA |
| Publisher: CELL PRESS, 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: 449BK |
| ISSN: 0092-8674 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |