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| Acetic acid feeding enhances glycogen repletion in liver and skeletal muscle of rats |
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| Author(s): Fushimi T, Tayama K, Fukaya M, Kitakoshi K, Nakai N, Tsukamoto Y, Sato Y |
| Source: JOURNAL OF NUTRITION Volume: 131 Issue: 7 Pages: 1973-1977 Published: JUL 2001 |
| Times Cited: 22 References: 50 |
| Abstract: To investigate the efficacy of the ingestion of vinegar in aiding recovery from fatigue, we examined the effect of dietary acetic acid, the main component of vinegar, on glycogen repletion in rats. Rats were allowed access to a commercial diet twice daily for 6 d. After 15 h of food deprivation, they were either killed immediately or given 2 g of a diet containing 0 (control), 0.1, 0.2 or 0.4 g acetic acid/100 g diet for 2 h. The 0.2 g acetic acid group had significantly greater liver and gastrocnemius muscle glycogen concentration than the control group (P < 0.05). The concentrations of citrate in this group in both the liver and skeletal muscles were >1.3-fold greater than in the control group (P > 0.1). In liver, the concentration of xylulose-5-phosphate in the control group was significantly higher than in the 0.2 and 0.4 g acetic acid groups (P < 0.01). In gastrocnemius muscle, the concentration of glucose-6-phosphate in the control group was significantly lower and the ratio of fructose-1,6-bisphosphate/fructose-6-phosphate was significantly higher than in the 0.2 g acetic acid group (P < 0.05). This ratio in the soleus muscle of the acetic acid fed groups was <0.8-fold that of the control group (P > 0.1). In liver, acetic acid may activate gluconeogenesis and inactivate glycolysis through inactivation of fructose-2, 6-bisphosphate synthesis due to suppression of xylulose-5-phosphate accumulation. In skeletal muscle, acetic acid may inhibit glycolysis by suppression of phosphofructokinase-1 activity. We conclude that a diet containing acetic acid may enhance glycogen repletion in liver and skeletal muscle. |
| Document Type: Proceedings Paper |
| Language: English |
| Reprint Address: Fushimi, T (reprint author), Mitsukan Grp Co Ltd, Cent Res Inst, Handa 4758585, Japan |
Addresses:
1. Mitsukan Grp Co Ltd, Cent Res Inst, Handa 4758585, Japan
2. Nagoya Univ, Res Ctr Hlth Phys Fitness & Sports, Nagoya, Aichi 4648601 Japan |
| Publisher: AMER INST NUTRITION, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA |
| Subject Category: Nutrition & Dietetics |
| IDS Number: 452BH |
| ISSN: 0022-3166 |
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