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| A MAP kinase-dependent actin checkpoint ensures proper spindle orientation in fission yeast |
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| Author(s): Gachet Y, Tournier S, Millar JBA, Hyams JS |
| Source: NATURE Volume: 412 Issue: 6844 Pages: 352-355 Published: JUL 19 2001 |
| Times Cited: 88 References: 28 |
| Abstract: The accurate segregation of chromosomes at mitosis depends on a correctly assembled bipolar spindle that exerts balanced forces on each sister chromatid(1,2). The integrity of mitotic chromosome segregation is ensured by the spindle assembly checkpoint (SAC) that delays mitosis in response to defective spindle organisation or failure of chromosome attachment(2,3). Here we describe a distinct mitotic checkpoint in the fission yeast, Schizosaccharomyces pombe, that monitors the integrity of the actin cytoskeleton and delays sister chromatid separation, spindle elongation and cytokinesis until spindle poles have been properly oriented. This mitotic delay is imposed by a stress-activated mitogen-activated protein (MAP) kinase pathway but is independent of the anaphase-promoting complex (APC)(4,5). |
| Document Type: Article |
| Language: English |
| Reprint Address: Millar, JBA (reprint author), Natl Inst Med Res, Div Yeast Genet, Ridgeway,Mill Hill, London NW7 1AA, England |
Addresses:
1. Natl Inst Med Res, Div Yeast Genet, London NW7 1AA, England
2. UCL, Dept Biol, London WC1E 6B, England |
| Publisher: MACMILLAN PUBLISHERS LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 453LW |
| ISSN: 0028-0836 |
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