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| Recent origin of Plasmodium falciparum from a single progenitor |
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| Author(s): Volkman SK, Barry AE, Lyons EJ, Nielsen KM, Thomas SM, Choi M, Thakore SS, Day KP, Wirth DF, Hartl DL |
| Source: SCIENCE Volume: 293 Issue: 5529 Pages: 482-484 Published: JUL 20 2001 |
| Times Cited: 89 References: 33 |
| Abstract: Genetic variability of Plasmodium falciparum underlies its transmission success and thwarts efforts to control disease caused by this parasite. Genetic variation in antigenic, drug resistance, and pathogenesis determinants is abundant, consistent with an ancient origin of P. falciparum, whereas DNA variation at silent (synonymous) sites in coding sequences appears virtually absent, consistent with a recent origin of the parasite. To resolve this paradox, we analyzed introns and demonstrated that these are deficient in single-nucleotide polymorphisms, as are synonymous sites in coding regions. These data establish the recent origin of P. falciparum and further provide an explanation for the abundant diversity observed in antigen and other selected genes. |
| Document Type: Article |
| Language: English |
| Reprint Address: Wirth, DF (reprint author), Harvard Univ, Sch Publ Hlth, Harvard Oxford Genome Divers Project, 665 Huntington Ave, Boston, MA 02115 USA |
Addresses:
1. Harvard Univ, Sch Publ Hlth, Harvard Oxford Genome Divers Project, Boston, MA 02115 USA
2. Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
3. Univ Oxford, Dept Zool, Oxford OX1 3PS, England
4. Harvard Univ, Dept Organism & Evolutionary Biol, Cambridge, MA 02138 USA
5. Norwegian Univ Sci & Technol, Dept Bot, N-7491 Trondheim, Norway |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 454HG |
| ISSN: 0036-8075 |
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