| | |  | | | | Record from Web of Science® | | | | | | |
| Lipoxygenases and their involvement in programmed cell death |
|
|
| Author(s): Maccarrone M, Melino G, Finazzi-Agro A |
| Source: CELL DEATH AND DIFFERENTIATION Volume: 8 Issue: 8 Pages: 776-784 Published: AUG 2001 |
| Times Cited: 60 References: 55 |
| Abstract: Lipoxygenases are a family of enzymes which dioxygenate unsaturated fatty acids, thus initiating lipoperoxidation of membranes and the synthesis of signaling molecules. Consequently, they induce structural and metabolic changes in the cell in a number of pathophysiological conditions. Recently, a pro-apoptotic effect of lipoxygenase, and of the hydroperoxides produced thereof, has been reported in different cells and tissues, leading to cell death. Anti-apoptotic effects of lipoxygenases have also been reported; however, this has often been based on the use of enzyme inhibitors, Here we review the characteristics of the lipoxygenase family and its involvement in the initiation of oxidative stress-induced apoptosis. Finally, we discuss the role of lipoxygenase activation in apoptosis of animal and plant cells, suggesting a common signal transduction pathway in cell death conserved through evolution of both kingdoms. |
| Document Type: Review |
| Language: English |
| Reprint Address: Finazzi-Agro, A (reprint author), Univ Roma Tor Vergata, Dept Expt Med & Biochem Sci, Via Tor Vergata 135, I-00133 Rome, Italy |
Addresses:
1. Univ Roma Tor Vergata, Dept Expt Med & Biochem Sci, I-00133 Rome, Italy |
| Publisher: NATURE PUBLISHING GROUP, HOUNDMILLS, BASINGSTOKE RG21 6XS, HAMPSHIRE, ENGLAND |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: 454YN |
| ISSN: 1350-9047 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |