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| Redox modulation of T-type calcium channels in rat peripheral nociceptors |
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| Author(s): Todorovic SM, Jevtovic-Todorovic V, Meyenburg A, Mennerick S, Perez-Reyes E, Romano C, Olney JW, Zorumski CF |
| Source: NEURON Volume: 31 Issue: 1 Pages: 75-85 Published: JUL 19 2001 |
| Times Cited: 91 References: 40 |
| Abstract: Although T-type calcium channels were first described in sensory neurons, their function in sensory processing remains unclear. In isolated rat sensory neurons, we show that redox agents modulate T currents but not other voltage- and ligand-gated channels thought to mediate pain sensitivity. Similarly, redox agents modulate currents through Ca(v)3.2 recombinant channels. When injected into peripheral receptive fields, reducing agents, including the endogenous amino acid L-cysteine, induce thermal hyperalgesia. This hyperalgesia is blocked by the oxidizing agent 5,5'-dithio-bis-(2-nitrobenzoic acid) (DTNB) and the T channel antagonist mibefradil. DTNB alone and in combination with mibefradil induces thermal analgesia. Likewise, L-cysteine induces mechanical DTNB-sensitive hyperalgesia in peripheral receptive fields. These data strongly suggest a role for T channels in peripheral nociception. Redox sites on T channels in peripheral nociceptors could be important targets for agents that modify pain perception. |
| Document Type: Article |
| Language: English |
| Reprint Address: Todorovic, SM (reprint author), Washington Univ, Sch Med, Dept Anesthesiol, St Louis, MO 63110 USA |
Addresses:
1. Washington Univ, Sch Med, Dept Anesthesiol, St Louis, MO 63110 USA
2. Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA
3. Washington Univ, Sch Med, Dept Ophthalmol, St Louis, MO 63110 USA
4. Univ Virginia, Dept Pharmacol, Charlottesville, VA 22908 USA |
| Publisher: CELL PRESS, 1100 MASSACHUSETTES AVE,, CAMBRIDGE, MA 02138 USA |
| Subject Category: Neurosciences |
| IDS Number: 456UR |
| ISSN: 0896-6273 |
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