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| Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients |
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| Author(s): Kang TJ, Chae GT |
| Source: FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY Volume: 31 Issue: 1 Pages: 53-58 Published: JUL 2001 |
| Times Cited: 130 References: 30 |
| Abstract: Toll-like receptor 2 (TLR2) is critical in the immune response to mycobacterial infections and the mutations in the TLR2 have been shown to confer the susceptibility to severe infection with mycobacteria. To define this, we screened the intracellular domain of TLR2 in 131 subjects. Groups of 45 lepromatous and 41 tuberculoid leprosy (TT) patients and 45 controls were investigated. Ten subjects among the lepromatous leprosy (LL) patients had a band variant detected by single-stranded conformational polymorphism. DNA sequencing detected a C to T substitution at nucleotide 2029 from the start codon of the TLR2. The mutation would substitute Arg to Trp at amino acid residue 677, one of the conserved regions of TLR2. In our results, the mutation was involved in only LL, not TT and control. Thus, we suggest that the mutation in the intracellular domain of TLR2 has a role in susceptibility to LL. (C) 2001 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved. |
| Document Type: Article |
| Language: English |
| Reprint Address: Chae, GT (reprint author), Catholic Univ Korea, Coll Med, Dept Pathol, Inst Hansens Dis, 505 Banpo Dong, Seoul 137701, South Korea |
Addresses:
1. Catholic Univ Korea, Coll Med, Dept Pathol, Inst Hansens Dis, Seoul 137701, South Korea |
| Publisher: ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS |
| Subject Category: Immunology; Infectious Diseases; Microbiology |
| IDS Number: 459QV |
| ISSN: 0928-8244 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |