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| Genetic changes in paired atypical and usual ductal hyperplasia of the breast by comparative genomic hybridization |
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| Author(s): Gong G, DeVries S, Chew KL, Cha I, Ljung BM, Waldman FM |
| Source: CLINICAL CANCER RESEARCH Volume: 7 Issue: 8 Pages: 2410-2414 Published: AUG 2001 |
| Times Cited: 44 References: 23 |
| Abstract: Purpose: Breast cancer is thought to develop from noninvasive precursor lesions, although the earliest steps of neoplastic transformation are still undefined. Usual ductal hyperplasia (UDH) is considered to represent a benign proliferation of ductal epithelial cells, whereas atypical ductal hyperplasia (ADH) may represent the first clonal neoplastic expansion of these cells. The aim of this study was to examine genetic alterations in UDH and ADH and to determine the relationship between these lesions in the same breast biopsy. Experimental Design: Comparative genomic hybridization analysis was used to define copy number alterations in DNA extracted from archival sections of 18 patients. Nine patients showed ADH with adjacent UDH, and nine showed pure UDH. None showed evidence of invasive cancer or ductal carcinoma in situ.
Results: Five of the nine ADH lesions showed chromosome copy number alterations. 16q loss (five cases) and 17p loss (two cases) were the most frequent changes. The associated UDH lesions in these five patients also showed copy number alterations, always a subset of the changes present in the paired ADH. In one other patient, the UDH showed eight chromosomal alterations, whereas the paired ADH showed no changes. Only one of nine cases with pure UDH showed comparative genomic hybridization abnormalities.
Conclusions: These data support the likelihood that UDH is a precursor of ADH, at least in some cases representing neoplastic growth. The frequencies of 16q and 17p losses suggest that alterations of candidate genes located in these chromosomal regions may play a role early in breast carcinogenesis.
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| Document Type: Article |
| Language: English |
| Reprint Address: Waldman, FM (reprint author), Univ Calif San Francisco, Ctr Canc, San Francisco, CA 94143 USA |
Addresses:
1. Univ Calif San Francisco, Ctr Canc, San Francisco, CA 94143 USA
2. Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA
3. Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA
4. Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pathol, Seoul 138736, South Korea |
| Publisher: AMER ASSOC CANCER RESEARCH, PO BOX 11806, BIRMINGHAM, AL 35202 USA |
| Subject Category: Oncology |
| IDS Number: 460VB |
| ISSN: 1078-0432 |
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