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| Translating the histone code |
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| Author(s): Jenuwein T, Allis CD |
| Source: SCIENCE Volume: 293 Issue: 5532 Pages: 1074-1080 Published: AUG 10 2001 |
| Times Cited: 2,857 References: 93 |
| Abstract: Chromatin, the physiological template of all eukaryotic genetic information, is subject to a diverse array of posttranslational modifications that largely impinge on histone amino termini, thereby regulating access to the underlying DNA. Distinct histone amino-terminal modifications can generate synergistic or antagonistic interaction affinities for chromatin-associated proteins, which in turn dictate dynamic transitions between transcriptionally active or transcriptionally silent chromatin states. The combinatorial nature of histone amino-terminal modifications thus reveals a "histone code" that considerably extends the information potential of the genetic code. We propose that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development. |
| Document Type: Review |
| Language: English |
| Reprint Address: Jenuwein, T (reprint author), Vienna Bioctr, Res Inst Mol Pathol, Dr Bohrgasse 7, A-1030 Vienna, Austria |
Addresses:
1. Vienna Bioctr, Res Inst Mol Pathol, A-1030 Vienna, Austria
2. Univ Virginia, Hlth Sci Ctr, Dept Biochem & Mol Biol, Charlottesville, VA 22908 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 462RB |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |