| Anoikis mechanisms |
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| Author(s): Frisch SM, Screaton RA |
| Source: CURRENT OPINION IN CELL BIOLOGY Volume: 13 Issue: 5 Pages: 555-562 Published: OCT 2001 |
| Times Cited: 497 References: 72 |
| Abstract: Anoikis is defined as apoptosis that is induced by inadequate or inappropriate cell-matrix interactions. It is involved in a wide diversity of tissue-homeostatic, developmental and oncogenic processes. The central problem of anoikis is to understand how integrin-mediated cell adhesion signals control the apoptotic machinery. In particular, the initiation of the caspase cascade in anoikis remains to be explained. |
| Document Type: Review |
| Language: English |
| Reprint Address: Frisch, SM (reprint author), Burnham Inst, 10901 N Torrey Pines Rd, La Jolla, CA 92037 USA |
Addresses:
1. Burnham Inst, La Jolla, CA 92037 USA |
| Publisher: CURRENT BIOLOGY LTD, 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND |
| Subject Category: Cell Biology |
| IDS Number: 469TL |
| ISSN: 0955-0674 |