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| Biology of EWS/ETS fusions in Ewing's family tumors |
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| Author(s): Arvand A, Denny CT |
| Source: ONCOGENE Volume: 20 Issue: 40 Pages: 5747-5754 Published: SEP 10 2001 |
| Times Cited: 143 References: 108 |
| Abstract: Tumor-associated chromosomal translocations lead to the formation of chimeric fusions between the EWS gene and one of five different ETS transcription factors in Ewing's family tumors (EFTs). The resultant EWS/ETS proteins promote oncogenesis in a dominant fashion in model systems and are necessary for continued growth of EFT cell lines. EWS belongs to a family of genes that encode proteins that may serve as adapters between the RNA polymerase II complex and RNA splicing factors. EWS/ETS fusions have biochemical characteristics of aberrant transcription factors and appear to promote abnormal cellular growth by transcriptionally modulating a network of target genes. Early evidence suggests that EWS/ETS proteins may also impact gene expression through alteration in RNA processing. Elucidation of EWS/ETS target gene networks in the context of other signaling pathways will hopefully lead to biology based therapeutic strategies for EFT. |
| Document Type: Review |
| Language: English |
| Reprint Address: Denny, CT (reprint author), Univ Calif Los Angeles, Inst Mol Biol, Gwynee Hazen Cherry Mem Lab, Los Angeles, CA 90024 USA |
Addresses:
1. Univ Calif Los Angeles, Inst Mol Biol, Gwynee Hazen Cherry Mem Lab, Los Angeles, CA 90024 USA
2. Univ Calif Los Angeles, Jonsson Comprehens Ctr, Gwynee Hazen Cherry Mem Lab, Los Angeles, CA 90024 USA
3. Univ Calif Los Angeles, Dept Pathol & Lab Med, Gwynee Hazen Cherry Mem Lab, Los Angeles, CA 90024 USA
4. Univ Calif Los Angeles, Dept Pediat, Gwynee Hazen Cherry Mem Lab, Los Angeles, CA 90024 USA |
| Publisher: NATURE PUBLISHING GROUP, HOUNDMILLS, BASINGSTOKE RG21 6XS, HAMPSHIRE, ENGLAND |
| Subject Category: Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity |
| IDS Number: 470TP |
| ISSN: 0950-9232 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |