| | |  | | | | Record from Web of Science® | | | | | | |
| Prophylaxis for paclitaxel hypersensitivity reactions |
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| Author(s): Kintzel PE |
| Source: ANNALS OF PHARMACOTHERAPY Volume: 35 Issue: 9 Pages: 1114-1117 Published: SEP 2001 |
| Times Cited: 8 References: 14 |
| Abstract: OBJECTIVE: To evaluate clinical literature supporting the prophylactic use of single-dose intravenous dexamethasone to prevent hypersensitivity reactions (HSRs) to paclitaxel infusion. DATA SOURCES: Clinical literature accessed through MEDLINE (from 1986 to 2000).
DATA SYNTHESIS: Prophylaxis for paclitaxel-related HSRs generally includes repeated dexamethasone doses beginning 12 hours before paclitaxel, and administration of diphenhydramine plus a histamine(2)-receptor antagonist 30 minutes before infusion of paclitaxel. Single-dose intravenous dexamethasone administered with ancillary medications 30 minutes before infusion of paclitaxel has been used to prevent regimen-related HSRs.
CONCLUSIONS: Single-dose intravenous dexamethasone can be used in combination with appropriate ancillary medications to prevent paclitaxel-related HSRs.
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| Document Type: Article |
| Language: English |
| Reprint Address: Kintzel, PE (reprint author), Detroit Med Ctr, Harper Univ Hosp, Barbara Ann Karmanos Canc Inst, Dept Pharm,Cell Transplant Program, 3990 John R, Detroit, MI 48201 USA |
Addresses:
1. Detroit Med Ctr, Harper Univ Hosp, Barbara Ann Karmanos Canc Inst, Dept Pharm,Cell Transplant Program, Detroit, MI 48201 USA |
| Publisher: HARVEY WHITNEY BOOKS CO, PO BOX 42696, CINCINNATI, OH 45242 USA |
| Subject Category: Pharmacology & Pharmacy |
| IDS Number: 473KV |
| ISSN: 1060-0280 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |