| | |  | | | | Record from Web of Science® | | | | | | |
| A polymorphism in the enhancer region of the thymidylate synthase promoter influences the survival of colorectal cancer patients treated with 5-fluorouracil |
|
|
| Author(s): Iacopetta B, Grieu F, Joseph D, Elsaleh H |
| Source: BRITISH JOURNAL OF CANCER Volume: 85 Issue: 6 Pages: 827-830 Published: SEP 14 2001 |
| Times Cited: 118 References: 19 |
| Abstract: High levels of thymidylate synthase (TS) expression have been associated with poor survival of colorectal cancer (CRC) patients to 5-fluorouracil (5-FU)-based chemotherapy. Recent evidence suggests that a polymorphism within the enhancer region of the TS gene promoter can influence TS expression, with the triple repeat homozygote (3R/3R) being associated with significantly higher tumour TS levels than either the double repeat homozygote (2R/2R) or heterozygotes (2R/3R). In the present study we investigated whether TS genotype was associated with the degree of survival benefit from chemotherapy in 221 Dukes' C stage CRC patients. Patients with the 3R/3R polymorphism (n = 58, 26%) showed no significant long-term survival benefit from chemotherapy (RR = 0.62, 95% CI: 0.30-1.25, P = 0.18), whereas those with the 2R/2R or 2R/3R genotype (n = 163, 74%) showed significant gains in survival from this treatment (RR = 0,52, 95% CI: 0.52-0.82, P = 0.005). These results demonstrate that a polymorphism within the TS gene, probably through its effect on TS expression levels, can influence the survival benefit obtained by CRC patients from 5-FU-based chemotherapy. (C) 2001 Cancer Research Campaign. |
| Document Type: Article |
| Language: English |
| Reprint Address: Iacopetta, B (reprint author), Univ Western Australia, Dept Surg, Nedlands, WA 6907 Australia |
Addresses:
1. Univ Western Australia, Dept Surg, Nedlands, WA 6907 Australia
2. Sir Charles Gairdner Hosp, Dept Radiat Oncol, Nedlands, WA 6009 Australia
3. Univ Western Australia, Dept Med, Nedlands, WA 6907 Australia |
| Publisher: CHURCHILL LIVINGSTONE, JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND |
| Subject Category: Oncology |
| IDS Number: 481TL |
| ISSN: 0007-0920 |
| DOI: 10.1054/bjoc.2001.2007 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |