| PKB/AKT: Functional insights from genetic models |
|
|
| Author(s): Scheid MP, Woodgett JR |
| Source: NATURE REVIEWS MOLECULAR CELL BIOLOGY Volume: 2 Issue: 10 Pages: 760-768 Published: OCT 2001 |
| Times Cited: 284 References: 94 |
| Abstract: Since its discovery 10 years ago, the potential functions of protein kinase B (PKB)/AKT have been catalogued with increasing efficiency. The physiological relevance of some of the proposed mechanisms by which PKB/AKT mediates many of its effects has been questioned, and recent work using new reagents and approaches has revealed some cracks in our understanding of this important molecule, and also hinted that these effects may involve other players. |
| Document Type: Review |
| Language: English |
| Reprint Address: Woodgett, JR (reprint author), Ontario Canc Inst, 610 Univ Ave, Toronto, ON M5G 2M9 Canada |
Addresses:
1. Ontario Canc Inst, Toronto, ON M5G 2M9 Canada |
| Publisher: NATURE PUBLISHING GROUP, HOUNDMILLS, BASINGSTOKE RG21 6XS, HAMPSHIRE, ENGLAND |
| Subject Category: Cell Biology |
| IDS Number: 481ZP |
| ISSN: 1471-0072 |