| | |  | | | | Record from Web of Science® | | | | | | |
| Chemokine receptors |
|
|
| Author(s): Horuk R |
| Source: CYTOKINE & GROWTH FACTOR REVIEWS Volume: 12 Issue: 4 Pages: 313-335 Published: DEC 2001 |
| Times Cited: 188 References: 198 |
| Abstract: Although chemokines were originally defined as host defense proteins it is now clear that their repertoire of functions extend well beyond this role. For example chemokines such as MGSA have growth regulatory properties while members of the CXC chemokine family can be mediators or inhibitors of angiogenesis and may be important targets for oncology. Recent work shows that the chemokine receptor CXCR4 and its cognate ligand SDF play important roles in the development of the immune. circulatory and central nervous systems. In addition, chemokine receptors play an important role in the pathogenesis of the AIDS virus, HIV-1. Taken together these findings expand the biological importance of chemokines from that of simple immune modulators to a much broader biological role than was at first appreciated and these and other properties of the chemokine receptor family are discussed in detail in this review. (C) 2001 Elsevier Science Ltd. All rights reserved. |
| Document Type: Review |
| Language: English |
| Reprint Address: Horuk, R (reprint author), Berlex Biosci, Dept Immunol, 15049 San Pablo Ave, Richmond, CA 94804 USA |
Addresses:
1. Berlex Biosci, Dept Immunol, Richmond, CA 94804 USA |
| Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: 483ZX |
| ISSN: 1359-6101 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |