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Uremic toxicity: present state of the art
Author(s): Vanholder R, Argiles A, Baurmeister U, Brunet P, Clark W, Cohen G, De Deyn PP, Deppisch R, Descamps-Latscha B, Henle T, Jorres A, Massy ZA, Rodriguez M, Stegmayr B, Stenvinkel P, Wratten ML
Source: INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS    Volume: 24    Issue: 10    Pages: 695-725    Published: OCT 2001  
Times Cited: 100     References: 334     
Abstract: The uremic syndrome is a complex mixture of organ dysfunctions, which is attributed to the retention of a myriad of compounds that under normal condition are excreted by the healthy kidneys (uremic toxins). In the area of identification and characterization of uremic toxins and in the knowledge of their pathophysiologic importance, major steps forward have been made during recent years. The present article is a review of several of these steps, especially in the area of information about the compounds that could play a role in the development of cardiovascular complications. It is written by those members of the Uremic Toxins Group, which has been created by the European Society for Artificial Organs (ESAO). Each of the 16 authors has written a state of the art in his/her major area of interest.
Document Type: Review
Language: English
Reprint Address: Vanholder, R (reprint author), State Univ Ghent Hosp, Dept Internal Med, Nephrol Sect, De Pintelaan 185, B-9000 Ghent, Belgium
Addresses:
1. State Univ Ghent Hosp, Dept Internal Med, Nephrol Sect, B-9000 Ghent, Belgium
2. Inst Human Genet, IGH, CNRS, UPR 1142, Montpellier, France
3. Membrana GmbH, Wuppertal, Germany
4. Hop St Marguerite, Marseille, France
5. Baxter Healthcare Corp, Lessines, Belgium
6. Univ Vienna, Dept Med, Div Nephrol, Vienna, Austria
7. Univ Antwerp, Middelheim Hosp, Dept Neurol, Lab Neurochem & Behav, Antwerp, Belgium
8. Gambro Corp Res, Hechingen, Germany
9. Hop Necker Enfants Malad, INSERM, U507, Paris, France
10. Tech Univ Dresden, Inst Food Chem, D-8027 Dresden, Germany
11. Humboldt Univ, Fac Med, UK Charite, Berlin, Germany
12. Hop Necker Enfants Malad, INSERM, U507, Paris, France
13. CH Beauvals, Div Nephrol, Paris, France
14. Univ Hosp Reina Sofia, Res Inst, Cordoba, Spain
15. Norrlands Univ Hosp, Med Clin, Umea, Sweden
16. Huddinge Univ Hosp, Dept Nephrol, S-14186 Huddinge, Sweden
17. Bellco SPA, Mirandola, Italy
Publisher: WICHTIG EDITORE, 72/74 VIA FRIULI, 20135 MILAN, ITALY
Subject Category: Engineering, Biomedical; Transplantation
IDS Number: 494LQ
ISSN: 0391-3988
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