| | |  | | | | Record from Web of Science® | | | | | | |
| Prostaglandins and leukotrienes: Advances in eicosanoid biology |
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| Author(s): Funk CD |
| Source: SCIENCE Volume: 294 Issue: 5548 Pages: 1871-1875 Published: NOV 30 2001 |
| Times Cited: 943 References: 64 |
| Abstract: Prostaglandins and leukotrienes are potent eicosanoid lipid mediators derived from phospholipase-released arachidonic acid that are involved in numerous homeostatic biological functions and inflammation. They are generated by cyclooxygenase isozymes and 5-lipoxygenase, respectively, and their biosynthesis and actions are blocked by clinically relevant nonsteroidal anti-inflammatory drugs, the newer generation coxibs (selective inhibitors of cyclooxygenase-2), and Leukotriene modifiers. The prime mode of prostaglandin and Leukotriene action is through specific G protein-coupled receptors, many of which have been cloned recently, thus enabling specific receptor agonist and antagonist development Important insights into the mechanisms of inflammatory responses, pain, and fever have been gleaned from our current understanding of eicosanoid biology. |
| Document Type: Review |
| Language: English |
| Reprint Address: Funk, CD (reprint author), Univ Penn, Ctr Expt Therapeut, Philadelphia, PA 19104 USA |
Addresses:
1. Univ Penn, Ctr Expt Therapeut, Philadelphia, PA 19104 USA
2. Univ Penn, Dept Pharmacol, Philadelphia, PA 19104 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 497PQ |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |