| | |  | | | | Record from Web of Science® | | | | | | |
| Physiological migration of hematopoietic stem and progenitor Celts |
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| Author(s): Wright DE, Wagers AJ, Gulati AP, Johnson FL, Weissman IL |
| Source: SCIENCE Volume: 294 Issue: 5548 Pages: 1933-1936 Published: NOV 30 2001 |
| Times Cited: 282 References: 23 |
| Abstract: Hematopoietic stem cells (HSCs) reside predominantly in bone marrow, but low numbers of HSCs are also found in peripheral blood. We examined the fate of blood-borne HSCs using genetically marked parabiotic mice, which are surgically conjoined and share a common circulation. Parabionts rapidly established stable, functional cross engraftment of partner-derived HSCs and maintained partner-derived hematopoiesis after surgical separation. Determination of the residence time of injected blood-borne progenitor cells suggests that circulating HSCs/progenitors: are cleared quickly from the blood, These data demonstrate that HSCs rapidly and constitutively migrate through the blood and play a physiological role in, at least, the functional reengraftment of unconditioned bone marrow. |
| Document Type: Article |
| Language: English |
| Reprint Address: Weissman, IL (reprint author), Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA |
Addresses:
1. Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA
2. Stanford Univ, Sch Med, Dept Dev Biol, Stanford, CA 94305 USA
3. Stanford Univ, Palo Alto Vet Affairs Hlth Care Syst, Sch Med, Dept Med,Cardiovasc Med Div,Cardiol Sect 111C, Palo Alto, CA 94304 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 497PQ |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |