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Allogeneic stem cell transplantation for Evans syndrome
Author(s): Oyama Y, Papadopoulos EB, Miranda M, Traynor AE, Burt RK
Source: BONE MARROW TRANSPLANTATION    Volume: 28    Issue: 9    Pages: 903-905    Published: NOV 2001  
Times Cited: 30     References: 21     
Abstract: Evans syndrome is a rare disorder characterized by combined autoimmune thrombocytopenia (ITP) and autoimmune hemolytic anemia (AIHA). Standard treatments consist of transfusions, corticosteroids, splenectomy, IVIG, anabolic steroids, vincristine, alkylating agents, or cyclosporine. In a patient with refractory disease, an allogeneic hematopoietic stem cell transplant (HSCT) resulted in complete clinical and serologic remission for more than 30 months. Allogeneic HSCT may be the only current curative therapy for Evans syndrome but may also be complicated by significant toxicities.
Document Type: Article
Language: English
Reprint Address: Burt, RK (reprint author), Northwestern Univ, Med Ctr, Div Immune Therapy & Autoimmune Dis, Chicago, IL 60611 USA
Addresses:
1. Northwestern Univ, Med Ctr, Div Immune Therapy & Autoimmune Dis, Chicago, IL 60611 USA
2. Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA
Publisher: NATURE PUBLISHING GROUP, HOUNDMILLS, BASINGSTOKE RG21 6XS, HAMPSHIRE, ENGLAND
Subject Category: Biophysics; Oncology; Hematology; Immunology; Transplantation
IDS Number: 498EH
ISSN: 0268-3369
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