| | |  | | | | Record from Web of Science® | | | | | | |
| beta-cell death during progression to diabetes |
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| Author(s): Mathis D, Vence L, Benoist C |
| Source: NATURE Volume: 414 Issue: 6865 Pages: 792-798 Published: DEC 13 2001 |
| Times Cited: 279 References: 100 |
| Abstract: The hallmark of type 1 diabetes is specific destruction of pancreatic islet beta -cells. Apoptosis of beta -cells may be crucial at several points during disease progression, initiating leukocyte invasion of the islets and terminating the production of insulin in islet cells. beta -Cell apoptosis may also be involved in the occasional evolution of type 2 into type 1 diabetes. |
| Document Type: Review |
| Language: English |
| Reprint Address: Mathis, D (reprint author), Brigham & Womens Hosp, Joslin Diabet Ctr, Dept Med, Sect Immunol & Innumogenet, 1 Joslin Pl, Boston, MA 02215 USA |
Addresses:
1. Brigham & Womens Hosp, Joslin Diabet Ctr, Dept Med, Sect Immunol & Innumogenet, Boston, MA 02215 USA
2. Harvard Univ, Sch Med, Boston, MA 02215 USA |
| Publisher: MACMILLAN PUBLISHERS LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 501GD |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |