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| C-reactive protein elevation in patients with atrial arrhythmias - Inflammatory mechanisms and persistence of atrial fibrillation |
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| Author(s): Chung MK, Martin DO, Sprecher D, Wazni O, Kanderian A, Carnes CA, Bauer JA, Tchou PJ, Niebauer MJ, Natale A, Van Wagoner DR |
| Source: CIRCULATION Volume: 104 Issue: 24 Pages: 2886-2891 Published: DEC 11 2001 |
| Times Cited: 335 References: 30 |
| Abstract: Background-Atrial Fibrillation (AF) may persist due to structural changes in the atria that are promoted by inflammation. C-reactive protein (CRP), a marker of systemic inflammation, predicts cardiovascular events and stroke, a common sequela of AF. We hypothesized that CRP is elevated in patients, with atrial arrhythmias. Methods and Results-Using a case-control study design, CRP in 131 patients with atrial arrhythmias was compared with CRP in 71 control patients. Among arrhythmia patients, 6 had frequent atrial ectopy or tachycardia, 86 had paroxysmal AF, 39 had persistent AF lasting > 30 days, and 70 had lone arrhythmias. CRP was higher in arrhythmia than in control patients (median, 0.21 versus 0.096 mg/dL; P <0.001). Arrhythmia patient,, in AF within 24 hours before sampling had higher CRP than those in sinus rhythm (0.30 versus 0.15 mg/dL; P <0.001). CRP in controls was not different than in patient,, with atrial ectopy or tachycardia. Lone arrhythmia patients had a CRP of 0.21 mg/dL, which was not significantly lower than arrhythmia patients with structural heart disease (CRP, 0.23 mg/dL) but higher than controls (P=0.002). Persistent AF patients had a higher CRP (0.34 mg/dL) than paroxysmal AF patients (0. 18 mg/dL, P=0.008); both groups had higher CRP levels than controls (P less than or equal to0.005). Conclusions-CRP is elevated in AF patients. This study is the first to document elevated CRP in non-postoperative arrhythmia patients. These findings are reinforced by stepwise CRP elevation with higher AF burden. Although the cause of elevated CRP levels in AF patients remains unknown, elevated CRP may reflect Lin inflammatory state that promotes the persistence of AF. |
| Document Type: Article |
| Language: English |
| Reprint Address: Chung, MK (reprint author), Cleveland Clin Fdn, Dept Cardiovasc Med, 9500 Euclid Ave,F-15, Cleveland, OH 44195 USA |
Addresses:
1. Cleveland Clin Fdn, Dept Cardiovasc Med, Cleveland, OH 44195 USA
2. Ohio State Univ, Coll Pharm, Columbus, OH 43210 USA
3. Ohio State Univ, Dorothy M Davis Heart & Lung Res Inst, Columbus, OH 43210 USA |
| Publisher: LIPPINCOTT WILLIAMS & WILKINS, 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA |
| Subject Category: Cardiac & Cardiovascular Systems; Hematology; Peripheral Vascular Disease |
| IDS Number: 501TC |
| ISSN: 0009-7322 |
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