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| MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia |
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| Author(s): Armstrong SA, Staunton JE, Silverman LB, Pieters R, de Boer ML, Minden MD, Sallan SE, Lander ES, Golub TR, Korsmeyer SJ |
| Source: NATURE GENETICS Volume: 30 Issue: 1 Pages: 41-47 Published: JAN 2002 |
| Times Cited: 658 References: 47 |
| Abstract: Acute lymphoblastic leukemias carrying a chromosomal translocation involving the mixed-lineage leukemia gene (MLL, ALL1, HRX) have a particularly poor prognosis. Here we show that they have a characteristic, highly distinct gene expression profile that is consistent with an early hematopoietic progenitor expressing select multilineage markers and individual HOX genes. Clustering algorithms reveal that lymphoblastic leukemias with MLL translocations can clearly be separated from conventional acute lymphoblastic and acute myelogenous leukemias. We propose that they constitute a distinct disease, denoted here as MLL, and show that the differences in gene expression are robust enough to classify leukemias correctly as MLL, acute lymphoblastic leukemia or acute myelogenous leukemia. Establishing that MLL is a unique entity is critical, as it mandates the examination of selectively expressed genes for urgently needed molecular targets. |
| Document Type: Article |
| Language: English |
| Reprint Address: Korsmeyer, SJ (reprint author), Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA |
Addresses:
1. Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA
2. Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA
3. Dana Farber Canc Inst, Howard Hughes Med Inst, Boston, MA 02115 USA
4. Childrens Hosp, Div Pediat Hematol Oncol, Boston, MA 02115 USA
5. Harvard Univ, Sch Med, Boston, MA 02115 USA
6. MIT, Whitehead Inst Biomed Res, Ctr Genome Res, Cambridge, MA 02142 USA
7. Univ Rotterdam, Sophia Childrens Hosp, Div Pediat Hematol Oncol, Rotterdam, Netherlands
8. Univ Toronto, Princess Margaret Hosp, Toronto, ON Canada |
| Publisher: NATURE AMERICA INC, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 USA |
| Subject Category: Genetics & Heredity |
| IDS Number: 508TL |
| ISSN: 1061-4036 |
| DOI: 10.1038/ng765 |
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