| | |  | | | | Record from Web of Science® | | | | | | |
| Apoptosis: A link between cancer genetics and chemotherapy |
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| Author(s): Johnstone RW, Ruefli AA, Lowe SW |
| Source: CELL Volume: 108 Issue: 2 Pages: 153-164 Published: JAN 25 2002 |
| Times Cited: 826 References: 101 |
| Abstract: Defects in apoptosis underpin both tumorigenesis and drug resistance, and because of these defects chemotherapy often fails. Understanding the molecular events that contribute to drug-induced apoptosis, and how tumors evade apoptotic death, provides a paradigm to explain the relationship between cancer genetics and treatment sensitivity and should enable a more rational approach to anticancer drug design and therapy. |
| Document Type: Review |
| Language: English |
| Reprint Address: Johnstone, RW (reprint author), Peter MacCallum Canc Inst, Canc Immunol Div, Trescowthick Res Labs, Smorgon Family Bldg,St Andrews Pl, Melbourne, Vic 3002 Australia |
Addresses:
1. Peter MacCallum Canc Inst, Canc Immunol Div, Trescowthick Res Labs, Melbourne, Vic 3002 Australia
2. Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA |
| Publisher: CELL PRESS, 1100 MASSACHUSETTS AVE,, CAMBRIDGE, MA 02138 USA |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: 515XE |
| ISSN: 0092-8674 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |