| | |  | | | | Record from Web of Science® | | | | | | |
| The JAK/STAT pathway is required for border cell migration during Drosophila oogenesis |
|
|
| Author(s): Beccari S, Teixeira L, Rorth P |
| Source: MECHANISMS OF DEVELOPMENT Volume: 111 Issue: 1-2 Pages: 115-123 Published: FEB 2002 |
| Times Cited: 61 References: 38 |
| Abstract: During Drosophila oogenesis, border cells perform a stereotypic migration. Slbo, a C/EBP transcription factor, is required for this migration. Here we identify Drosophila Stat92E (signal transducer and activator of transcription) in a screen for gain-of-function suppressors of the slbo mutant phenotype. By clonal analysis for Stat92E and hop (Drosophila JAK) mutants we find that the JAK/STAT pathway is required in border cells for their migration. The activating ligand for the pathway, Unpaired, is expressed in polar cells. Polar cells are specialized cells which can induce border cell fate in anterior follicle cells. On its own, ectopic expression of Unpaired can induce ectopic expression of border cell markers including Slbo. However, Stat92E mutant cells still express normal levels of Slbo protein, thus Stat92E must regulate other targets critical for border cell migration. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved. |
| Document Type: Article |
| Language: English |
| Reprint Address: Rorth, P (reprint author), European Mol Biol Lab, Dev Biol Programme, Meyerhofstr 1, D-69117 Heidelberg, Germany |
Addresses:
1. European Mol Biol Lab, Dev Biol Programme, D-69117 Heidelberg, Germany |
| Publisher: ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS |
| Subject Category: Developmental Biology |
| IDS Number: 519PA |
| ISSN: 0925-4773 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |