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| Luminescent quantum dots for multiplexed biological detection and imaging |
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| Author(s): Chan WCW, Maxwell DJ, Gao XH, Bailey RE, Han MY, Nie SM |
| Source: CURRENT OPINION IN BIOTECHNOLOGY Volume: 13 Issue: 1 Pages: 40-46 Published: FEB 2002 |
| Times Cited: 649 References: 45 |
| Abstract: Recent advances in nanomaterials have produced a new class of fluorescent labels by conjugating semiconductor quantum dots with biorecognition molecules. These nanometer-sized conjugates are water-soluble and biocompatible, and provide important advantages over organic dyes and lanthanide probes. In particular, the emission wavelength of quantum-dot nanocrystals can be continuously tuned by changing the particle size, and a single light source can be used for simultaneous excitation of all different-sized dots. High-quality dots are also highly stable against photobleaching and have narrow, symmetric emission spectra. These novel optical properties render quantum dots ideal fluorophores for ultrasensitive, multicolor, and multiplexing applications in molecular biotechnology and bioengineering. |
| Document Type: Review |
| Language: English |
| Reprint Address: Chan, WCW (reprint author), Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA |
Addresses:
1. Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA
2. Georgia Inst Technol, Wallace Coulter Dept Biomed Engn, Atlanta, GA 30322 USA
3. Emory Univ, Atlanta, GA 30322 USA
4. Inst Mat Res & Engn, Singapore 117602, Singapore
5. Natl Univ Singapore, Dept Mat Sci, Singapore 119260, Singapore
6. Emory Univ, Sch Med, Dept Chem, Atlanta, GA 30322 USA
7. Emory Univ, Sch Med, Dept Hematol & Oncol, Atlanta, GA 30322 USA
8. Emory Univ, Sch Med, Winship Canc Inst, Atlanta, GA 30322 USA |
| Publisher: CURRENT BIOLOGY LTD, 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND |
| Subject Category: Biochemical Research Methods; Biotechnology & Applied Microbiology |
| IDS Number: 519VG |
| ISSN: 0958-1669 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |