| | |  | | | | Record from Web of Science® | | | | | | |
| Messenger-RNA-binding proteins and the messages they carry |
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| Author(s): Dreyfuss G, Kim VN, Kataoka N |
| Source: NATURE REVIEWS MOLECULAR CELL BIOLOGY Volume: 3 Issue: 3 Pages: 195-205 Published: MAR 2002 |
| Times Cited: 464 References: 163 |
| Abstract: From sites of transcription in the nucleus to the outreaches of the cytoplasm, messenger RNAs are associated with RNA-binding proteins. These proteins influence pre-mRNA processing as well as the transport, localization, translation and stability of mRNAs. Recent discoveries have shown that one group of these proteins marks exon-exon junctions and has a role in mRNA export. These proteins communicate crucial information to the translation machinery for the surveillance of nonsense mutations and for mRNA localization and translation. |
| Document Type: Review |
| Language: English |
| Reprint Address: Dreyfuss, G (reprint author), Univ Penn, Sch Med, Howard Hughes Med Inst, Philadelphia, PA 19104 USA |
Addresses:
1. Univ Penn, Sch Med, Howard Hughes Med Inst, Philadelphia, PA 19104 USA
2. Univ Penn, Sch Med, Dept Biochem & Biophys, Philadelphia, PA 19104 USA
3. Seoul Natl Univ, Sch Biol Sci, Inst Mol Biol & Genet, Seoul, South Korea |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Cell Biology |
| IDS Number: 528DU |
| ISSN: 1471-0072 |
| DOI: 10.1038/nrm760 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |