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| High incidence of Kaposi sarcoma-associated herpesvirus-related non-Hodgkin lymphoma in patients with HIV infection and multicentric Castleman disease |
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| Author(s): Oksenhendler E, Boulanger E, Galicier L, Du MQ, Dupin N, Diss TC, Hamoudi R, Daniel MT, Agbalika F, Boshoff C, Clauvel JP, Isaacson PG, Meignin V |
| Source: BLOOD Volume: 99 Issue: 7 Pages: 2331-2336 Published: APR 1 2002 |
| Times Cited: 115 References: 35 |
| Abstract: Multicentric Castleman disease (MCD) is a distinct type of lymphoproliferative disorder associated with inflammatory symptoms and interleukin 6 (IL-6) dysregulation. In the context of human immunodeficiency virus (HIV) infection, MCD is associated with Kaposi sarcoma-associated herpesvirus, also called human herpesvirus type 8 (KSHV/HHV8). Within a prospective cohort study on 60 HIV-infected patients with MCD, and a median follow-up period of 20 months, 14 patients developed KSHV/HHV8-associated non-Hodgkin lymphoma (NHL): 3 "classic" KSHV/HHV8(+) Epstein-Barr virus-positive (EBV+) primary effusion lymphoma (PEL), 5 KSHV/HHV8(+) EBV(-)visceral large cell NHL with a PEL-like phenotype, and 13 plasmablastic lymphoma/leukemia (3/3 KSHV/HHV8(+) EBV-). The NHL incidence observed in this cohort study (101/1000 patient-years) is about 15-old:what is expected in the general HIV+ population. MCD-assoclated KSHV/HHV8(+) NFIL fell into 2 groups, suggesting different pathogenesis. The plasmablastic NHL likely represents the expansion of plasmablastic microlymphoma, from the MCD lesion and progression toward aggressive NHL. In contrast, the PEL and PEL-like NHL may implicate a different original infected cell whose growth is promoted by the cytokine-rich environment of the MCD lesions. (C) 2002 by The American Society of Hematology. |
| Document Type: Article |
| Language: English |
| Reprint Address: Oksenhendler, E (reprint author), Hop St Louis, Serv Immunol & Hematol, Dept Immunol & Heamtol,Dept Pathol, Hematol Lab,Lab Virol,CRC,Viral Oncol Grp, 1 Ave Claude Vellefaux, F-75010 Paris, France |
Addresses:
1. Hop St Louis, Serv Immunol & Hematol, Dept Immunol & Heamtol,Dept Pathol, Hematol Lab,Lab Virol,CRC,Viral Oncol Grp, F-75010 Paris, France
2. Hop Tarnier Cochin, Dept Dermatol, NADER, Paris, France
3. Royal Free & Univ Coll Med Sch, Dept Histopathol, London, England
4. UCL, Wolfson Inst Biomed Res, London, England |
| Publisher: AMER SOC HEMATOLOGY, 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA |
| Subject Category: Hematology |
| IDS Number: 533ZC |
| ISSN: 0006-4971 |
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