| | |  | | | | Record from Web of Science® | | | | | | |
| Molecular determinants for the tissue specificity of SERMs |
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| Author(s): Shang YF, Brown M |
| Source: SCIENCE Volume: 295 Issue: 5564 Pages: 2465-2468 Published: MAR 29 2002 |
| Times Cited: 518 References: 28 |
| Abstract: Selective estrogen receptor modulators (SERMs) mimic estrogen action in certain tissues while opposing it in others. The therapeutic effectiveness of SERMS such as tamoxifen and raloxifene in breast cancer depends on their antiestrogenic activity. In the uterus, however, tamoxifen is estrogenic. Here, we show that both tamoxifen and raloxifene induce the recruitment of corepressors to target gene promoters in mammary cells. In endometrial cells, tamoxifen, but not raloxifene, acts like estrogen by stimulating the recruitment of coactivators to a subset of genes. The estrogen-like activity of tamoxifen in the uterus requires a high level of steroid receptor coactivator 1 (SRC-1) expression. Thus cell type- and promoter-specific differences in coregulator recruitment determine the cellular response to SERMs. |
| Document Type: Article |
| Language: English |
| Reprint Address: Brown, M (reprint author), Dana Farber Canc Inst, Dept Adult Oncol, 44 Binney St, Boston, MA 02115 USA |
Addresses:
1. Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA 02115 USA
2. Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA
3. Harvard Univ, Sch Med, Boston, MA 02115 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 536QD |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |