| | |  | | | | Record from Web of Science® | | | | | | |
| Innate immune recognition |
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| Author(s): Janeway CA, Medzhitov R |
| Source: ANNUAL REVIEW OF IMMUNOLOGY Volume: 20 Pages: 197-216 Published: 2002 |
| Times Cited: 2,005 References: 109 |
| Abstract: The innate immune system is a universal and ancient form of host defense against infection. Innate immune recognition relies on a limited number of germline-encoded receptors. These receptors evolved to recognize conserved products of microbial metabolism produced by microbial pathogens, but not by the host. Recognition of these molecular structures allows the immune system to distinguish infectious nonself from noninfectious self. Toll-like receptors play a major role in pathogen recognition and initiation of inflammatory and immune responses. Stimulation of Toll-like receptors by microbial products leads to the activation of signaling pathways that result in the induction of antimicrobial genes and inflammatory cytokines. In addition, stimulation of Toll-like receptors triggers dendritic cell maturation and results in the induction of costimulatory molecules and increased antigen-presenting capacity. Thus, microbial recognition by Toll-like receptors helps to direct adaptive immune responses to antigens derived from microbial pathogens. |
| Document Type: Review |
| Language: English |
| Reprint Address: Janeway, CA (reprint author), Yale Univ, Sch Med, Immunobiol Sect, 333 Cedar St, New Haven, CT 06520 USA |
Addresses:
1. Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USA
2. Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA |
| Publisher: ANNUAL REVIEWS, 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 USA |
| Subject Category: Immunology |
| IDS Number: 541XV |
| ISSN: 0732-0582 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |