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| Receptor-mediated radiotherapy with Y-90-DOTA-(D)Phe(1)-Tyr(3)-octreotide: The experience of the European Institute of Oncology Group |
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| Author(s): Chinol M, Bodei L, Cremonesi M, Paganelli G |
| Source: SEMINARS IN NUCLEAR MEDICINE Volume: 32 Issue: 2 Pages: 141-147 Published: APR 2002 |
| Times Cited: 57 References: 29 |
| Abstract: High concentrations of subtype 2 somatostatin tumor receptors (sst(2)) are expressed in numerous tumors, enabling primary and metastatic masses to be localized by scintigraphy after injecting In-111-labeled somatostatin analogue octreotide. In addition to neuroendocrine tumors, somatostatin receptors have been identified on cancers of the central nervous system, breast, lung, and lymphatic tissue, and the use of radionuclide-labeled somatostatin analogues appeared promising for therapy as well as for diagnosis of such malignancies. The somatostatin analogue [DOTA-(D)Phe(1)-Tyr(3)] octreotide (DOTATOC) possesses favorable characteristics for its potential therapeutic use in that it shows high affinity for sst(2), moderately high affinity for sst(5) and intermediate affinity for sst(3), high hydrophilicity, stable and facile labeling with In-111 and Y-90. We began to investigate the potential therapeutic applications of Y-90 DOTATOC in 1997 by performing a thorough dosimetric study in 18 patients who were administered In-111 DOTATOC to estimate the absorbed doses during Y-90-DOTATOC therapy. Then, we moved on and treated an overall number of 256 patients, mostly recruited in 2 distinct protocols with and without the administration of kidney protecting agents, with Y-90 DOTATOC. No major acute reactions were observed up to the activity of 5.55 GBq per cycle. The MTD per cycle was defined as 5.18 GBq. Objective therapeutic responses were documented in more than 20% of patients in terms of partial and complete responses. The present article reports in details our clinical experience (still ongoing) and outcomes with the use of Y-30 DOTATOC. Copyright 2002, Elsevier Science (USA). All rights reserved.
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| Document Type: Review |
| Language: English |
| Reprint Address: Paganelli, G (reprint author), European Inst Oncol, Div Nucl Med, Via Ripamonti 435, I-20141 Milan, Italy |
Addresses:
1. European Inst Oncol, Div Nucl Med, I-20141 Milan, Italy |
| Publisher: W B SAUNDERS CO, INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA |
| Subject Category: Radiology, Nuclear Medicine & Medical Imaging |
| IDS Number: 542EE |
| ISSN: 0001-2998 |
| DOI: 10.1053/snuc.2002.31563 |
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