| | |  | | | | Record from Web of Science® | | | | | | |
| Genetic dissection of transcriptional regulation in budding yeast |
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| Author(s): Brem RB, Yvert G, Clinton R, Kruglyak L |
| Source: SCIENCE Volume: 296 Issue: 5568 Pages: 752-755 Published: APR 26 2002 |
| Times Cited: 470 References: 22 |
| Abstract: To begin to understand the genetic architecture of natural variation in gene expression, we carried out genetic linkage analysis of genomewide expression patterns in a cross between a laboratory strain and a wild strain of Saccharomyces cerevisiae. Over 1500 genes were differentially expressed between the parent strains. Expression levels of 570 genes were linked to one or more different loci, with most expression levels showing complex inheritance patterns. The loci detected by linkage felt largely into two categories: cis-acting modulators of single genes and trans-acting modulators of many genes. We found eight such trans-acting loci, each affecting the expression of a group of 7 to 94 genes of related function. |
| Document Type: Article |
| Language: English |
| Reprint Address: Kruglyak, L (reprint author), Fred Hutchinson Canc Res Ctr, 1100 Fairview Ave N,D4-100, Seattle, WA 98109 USA |
Addresses:
1. Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA
2. Howard Hughes Med Inst, Coconut Grove, FL 33133 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 546PD |
| ISSN: 0036-8075 |
| DOI: 10.1126/science.1069516 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |