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| Sequoia, a tramtrack-related zinc finger protein, functions as a pan-neural regulator for dendrite and axon morphogenesis in Drosophila |
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| Author(s): Brenman JE, Gao FB, Jan LY, Jan YN |
| Source: DEVELOPMENTAL CELL Volume: 1 Issue: 5 Pages: 667-677 Published: NOV 2001 |
| Times Cited: 34 References: 49 |
| Abstract: Morphological complexity of neurons contributes to their functional complexity. How neurons generate different dendritic patterns is not known. We identified the sequoia mutant from a previous screen for dendrite mutants. Here we report that Sequoia is a pan-neural nuclear protein containing two putative zinc fingers homologous to the DNA binding domain of Tramtrack. sequoia mutants affect the cell fate decision of a small subset of neurons but have global effects on axon and dendrite morphologies of most and possibly all neurons. In support of sequoia as a specific regulator of neuronal morphogenesis, microarray experiments indicate that sequoia may regulate downstream genes that are important for executing neurite development rather than altering a variety of molecules that specify cell fates. |
| Document Type: Article |
| Language: English |
| Reprint Address: Jan, YN (reprint author), Univ Calif San Francisco, Howard Hughes Med Inst, Dept Physiol, San Francisco, CA 94143 USA |
Addresses:
1. Univ Calif San Francisco, Howard Hughes Med Inst, Dept Physiol, San Francisco, CA 94143 USA
2. Univ Calif San Francisco, Howard Hughes Med Inst, Dept Biochem, San Francisco, CA 94143 USA |
| Publisher: CELL PRESS, 1100 MASSACHUSETTS AVE,, CAMBRIDGE, MA 02138 USA |
| Subject Category: Cell Biology; Developmental Biology |
| IDS Number: 546XM |
| ISSN: 1534-5807 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |