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| Drosophila's insulin/P13-kinase pathway coordinates cellular metabolism with nutritional conditions |
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| Author(s): Britton JS, Lockwood WK, Li L, Cohen SM, Edgar BA |
| Source: DEVELOPMENTAL CELL Volume: 2 Issue: 2 Pages: 239-249 Published: FEB 2002 |
| Times Cited: 162 References: 47 |
| Abstract: Studies in Drosophila have characterized insulin receptor/phosphoinositide 3-kinase (Inr/PI3K) signaling as a potent regulator of cell growth, but its function during development has remained uncertain. Here we show that inhibiting Inr/PI3K signaling phenocopies the cellular and organismal effects of starvation, whereas activating this pathway bypasses the nutritional requirement for cell growth, causing starvation sensitivity at the organismal level. Consistent with these findings, studies using a pleckstrin homology domain-green fluorescent protein (PH-GFP) fusion as an indicator for PI3K activity show that PI3K is regulated by the availability of dietary protein in vivo. Hence we surmise that an essential function of insulin/PI3K signaling in Drosophila is to coordinate cellular metabolism with nutritional conditions. |
| Document Type: Article |
| Language: English |
| Reprint Address: Edgar, BA (reprint author), Fred Hutchinson Canc Res Ctr, Div Basic Sci, 1100 Fairview Ave N, Seattle, WA 98109 USA |
Addresses:
1. Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USA
2. Fred Hutchinson Canc Res Ctr, Mol & Cellular Biol Program, Seattle, WA 98109 USA
3. European Mol Biol Lab, Dev Biol Program, D-69117 Heidelberg, Germany |
| Publisher: CELL PRESS, 1100 MASSACHUSETTS AVE,, CAMBRIDGE, MA 02138 USA |
| Subject Category: Cell Biology; Developmental Biology |
| IDS Number: 546XQ |
| ISSN: 1534-5807 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |